Sep. 14, 2018
Craniofacial Genetics: Where are we going?
We teamed up with colleagues Seth Weinberg (University of Pittsburgh) and Rob Cornell (University of Iowa) to curate a special craniofacial genetics collection for PLOS Genetics. We selected published papers in PLOS journals reflecting our particular areas of interest: craniofacial morphogenesis, dysmorphology and syndromes, and normal human facial variation. We highlighted papers that made substantial contributions to the craniofacial field and looked to the future in high-throughput functional studies, phenotyping, and genomics.
We’ll be presenting at the Consortium for Orthodontic Advances in Science and Technology (COAST) conference in Scottsdale, AZ in September. We’ll also be presenting a poster at the American Society of Human Genetics (ASHG) in San Diego, CA in October.
May 30, 2018
New preprints on bioRxiv!
We have two new preprints out on different aspects of heterogeneity in clefting. In "Genome Wide Interaction Studies Identify Sex-Specific Risk Alleles for Nonsyndromic Orofacial Clefts" we report new gene-by-sex interactions for cleft lip with or without cleft palate. In "A novel method for systematic genetic analysis and visualization of phenotypic heterogeneity applied to orofacial clefts" we developed a new analysis and visualization strategy to study genetic differences between cleft lip, cleft lip and palate, and cleft palate only.
March 26, 2018
We're presenting at ACPA!
We'll be at the 75th Annual American Cleft Palate-Craniofacial Association meeting in Pittsburgh, PA. Elizabeth will be presenting a talk, "A Systematic Analysis Of Orofacial Clefts Reveals Subtype-Specific Genetic Effects" at the Genetics Concurrent Session on Friday, April 13 at 11am. It looks to be a great session with a focus on a the genetic risk factors for subtle and not-so-subtle craniofacial phenotypes.
November 10, 2017
We have a new paper out on identifying a modifying locus that increases risk of cleft lip individually, in families, and in gene-gene interactions with loci associated with cleft lip with or without cleft palate. We don't know much about the biology of the locus or mechanistically how it changes risk for cleft lip, but it will be interesting to find out!
October 11, 2017
We're presenting at ASHG!
Our abstract "Identification of 16q21 as a modifier locus for orofacial cleft phenotypes" is one of the Reviewer's Choice Abstracts. Catch Elizabeth at Poster 2186 on Thursday, October 19 from 3-4pm.
September 1, 2017
The Leslie Lab is open!
The lab officially relocated to Emory University from the University of Pittsburgh. We are part of the Center for Computational and Quantitative Genetics in the Department of Human Genetics. We can't wait to get started!